Okay, so before I get into the meat of this, I'd like to request constructive suggestions only please.
A recently uncovered plot hook in our campaign is that Allie, a human-raised wolf shapeshifter in the team, wants kids eventually. Her boyfriend/mate is Balthazar Black, a human
high-functioning sociopath Black Mage whose player has confirmed out of play that if Allie were to die, it's pretty much guaranteed that Balthazar would go full toxic and begin absolutely decimating whatever faction was ultimately responsible for her death. And he wants to grant Allie's wish.
Now while adoption is of course on the table, Balthazar is nothing if not bull-headed. So he's approached a contact, a Doc that operates a Delta clinic, about the possibility of somehow figuring out how to give Allie a child that's actually theirs. Of course since Shapechange doesn't affect chromosome count (otherwise you'd be able to simply use Shapechang to dodge ritual magic due to the full-on genetic shift once you changed back) he can't just turn into a wolf and do the natural thing. The Doc promised to at least look into it, as while conventional medicine says it's not possible, conventional medicine also said that it wasn't possible to manipulate the Matrix through sheer mental power either thirty years ago.
So, my thought is that there are enough legends out there of shapeshifters having children with normal humans, that there may be a grain of truth buried in there somewhere. And there have to have been some fringe scientists and researchers that would have pursued the idea. As well as the possibility that some Megas may have investigated as ways to produce their own groups of company-loyal shapeshifters for use in their military forces or black bag operations. The biggest two possiblilties for doing this to my mind are MCT and Aztechnology, both of whom have a blatant disregard for sapient suffering head and shoulders above the other Megas, and are heavily involved in magical research. Other options include Sauder-Krup, or possibly some lore that Ghostwalker (aka Dollmaker) has kept hold of.
What I'm looking for are viable research lines that Mouse (the Doc contact) may find crumbs of, that could lead the team to places where the research would be held (and possibly other stuff for the rest of the team to make a profit off of in the bargain). I'd prefer for on-going experiments and tests rather than simply having it be mothballed in a server somewhere; though getting older research to help Mouse connect the dots is most definitely in the cards.
The final culmination I'm envisioning for all of this is (Matt, Lindsey, please don't read this if you're on here)
Any feedback, suggestions or constructive commentary would be very much welcomed.