I think the choice to start with the new Edition is a good one, so you have only the core rules to start and your "shadowrun-fu" can grow with the edition as more book get available.
As SR can get very complex very fast I always like to start out slow with "new guys".
For beginning just some small neighbourhood gang stuff, only small arms/knifes/clubs and some vehicles.
When you are comfortable with that you can grow out of there, first professional jobs, some Magic or Hacking or both, all added as fast or slow as you like, until you are deep into the shadows.
And always remember: SR might be complex, but with that comes a lot of freedom (more with every new book).
Bored of standard runs? Lots of options:
- Do your own runs! Can't get that one piece of Equipment? Talk to the GM, he might let you make your own run to get that ... you are the J now, nice change of perspective, right?
- Do not only play Shadowrunners, you can do campaigns with many different stuff, e.g.:
-- DocWagon HTRT
-- Coorporate Security
-- Military / Mercenary stuff
-- Protection for on-site research teams
-- (Para-) Critter Hunters
-- Pirates (YARRR!)
-- Organized Crime members
-- etc.
The list can be as long as your fantasy allows