My point being, "If you think something is a good idea game wise: Think of it being used against you"
Most people have "cool" ideas. Be it spells from other settings, to sci-fi weapons that defy basic science, but when it comes to implementation into an actual game, they fall flat.
This is such an idea. Simply because there is no balance to it and it seems ABUSE from the high heavens! This has all the hallmarks of a Mary Sue power. There is no counter, there is no/little resistance to it, it has a massive effect for a small cost, it replaces multiple options of offense, AND can be used to bypass negative qualities.
1: as a permanent effect, it can not be removed, reversed, or misspelled. Once it takes effect, that is it.
2: since it causes no damage or no physical harm, those that have negative qualities that prevent or reduce combat effectiveness through violence will just use this.
3: there is no point to use ANY other combat or control spells as this single one has no down sides! Low successes needed to remove a combatant from combat forever. No need to sustain. No need for multiple castings to reduce the health pool (a-la friendly, ball lightning, etc).
But, you have the power to do whatever you want at your table. Including introducing new spells, technology, threats, or abilities.